What is a Headache ?
A headache is pain or discomfort in the head or face. Headaches vary greatly in terms of the location and intensity of the pain, and how often the headaches occur. The brain tissue doesn’t have pain-sensitive nerve fibers and doesn’t feel pain. But, other parts of the head can be responsible for a headache including:
- A network of nerves that extends over the scalp
- Certain nerves in the face, mouth, and throat
- Muscles of the head, neck, and shoulders
- Blood vessels found along the surface and at the base of the brain
Different types of headaches include:
Migraine
In this type of headache, symptoms other than pain occur as part of the headache. Nausea and vomiting, lightheadedness, sensitivity to light (photophobia), and other visual symptoms typically occur with migraines. Migraines also have distinct phases. Not all people have each phase, however. The phases of a migraine headache may include:
- Premonition or prodromal phase. A change in mood or behavior may occur hours or days before the headache.
- Aura phase. A group of visual, sensory, or motor symptoms can precede the headache. Examples include vision changes, hallucinations, numbness, changes in speech, and muscle weakness.
- Headache phase. Period during the actual headache with throbbing pain on one or both sides of the head. Sensitivity to light and motion are common, as are depression, fatigue, and anxiety.
- Resolution phase. Pain lessens during this phase, but may be replaced with fatigue, irritability, and trouble concentrating. Some people feel refreshed after an attack, others do not.
Tension headaches
Tension headaches are the most common type of headache. Stress and tight muscles are often factors in tension-type headaches. Acetaminophen, butalbital, and caffeine is used to relieve tension headaches. Acetaminophen is in a class of medications called analgesics (pain relievers). It works by changing the way the body senses pain. Butalbital is in a class of medications called barbiturates. It works by having a relaxing effect on the brain and central nervous system (CNS). Caffeine is a CNS stimulant. It works by changing the amounts of certain natural substances in the brain.
These are common symptoms of a tension-type headache:
- Slow onset of the headache
- Head usually hurts on both sides
- Pain is dull or feels like a band or vice around the head
- Pain may involve the back part of the head or neck
- Pain is mild to moderate, but not severe
- Tension type headaches typically do not cause nausea, vomiting, or sensitivity to light (photophobia).
Cluster headaches
These are the most common symptoms of a cluster headache:
Cluster headaches usually occur in a series that may last weeks or months.
These are the most common symptoms of a cluster headache:
- Severe pain on one side of the head, usually behind one eye
- The eye that is affected may be red and watery with a droopy lid and small pupil
- Swelling of the eyelid
- Runny nose or congestion
- Swelling of the forehead
Medications for Headaches
If you get headache pain, medications can bring relief. You can buy some headache medications right off the shelf at the store. These drugs are known as over-the-counter (OTC) pain relievers. With other headache medications, you need a medical prescription. Your healthcare provider can help you figure out the best medicine for your needs.
There are three types of headache medications:
- Relief for pain and other symptoms.
- Abortive therapies to stop the process behind headache pain.
- Preventive therapy to reduce how often and how severe your headaches are.
What OTC medications can relieve headache symptoms?
These medications provide relief from headache symptoms, without a prescription:
Generic name: Aspirin
- Brand name: Bayer®, Bufferin®, Ecotrin®.
- Symptoms relieved: Fever and pain.
- Precautions and possible side effects: Heartburn, gastrointestinal (GI) bleeding, bronchospasm or constriction that causes narrowing of the airways, anaphylaxis and peptic ulcer. Don’t give aspirin to children under 14 years old. It can cause a rare but serious disease called Reye’s syndrome.
Generic name: Acetaminophen, paracetamol
- Brand name: Tylenol®.
- Symptoms relieved: Fever and pain.
- Precautions and possible side effects: Changes in blood counts and liver function, but side effects are rare if medication is taken as directed.
Generic name: Ibuprofen (NSAID, or nonsteroidal anti-inflammatory drug)
- Brand name: Advil®, Motrin IB®, Nuprin®.
- Symptoms relieved: Fever, pain and inflammation.
- Precautions and possible side effects: GI upset, GI bleeding, nausea, vomiting, rash and changes in liver function.
Generic Name: Naproxen sodium (NSAID)
- Brand name: Aleve®.
- Symptoms relieved: Pain.
- Precautions and possible side effects: GI upset, GI bleeding, nausea, vomiting, rash and changes in liver function.
What prescription medications can I take for headache symptom relief?
Talk to your healthcare provider to find out if any of these prescription medications may be right for you:
Generic name: Antiemetics promethazine HCI
- Form: Tablet, syrup, injection or suppository.
- Brand name: Phenergan®.
- Symptoms relieved: Nausea, vomiting.
- Precautions and possible side effects: Confusion, drowsiness, dizziness, GI upset, excitability, nightmares, uncontrollable muscle movements, and lip-smacking or chewing movements.
Generic name: Prochlorperazine
- Form: Suppository.
- Brand name: Compazine®.
- Symptoms relieved: Nausea, vomiting.
- Precautions and possible side effects: Confusion, drowsiness, dizziness, GI upset, excitability, nightmares, uncontrollable muscle movements, and lip-smacking or chewing.
Generic name: Trimethobenzamide HCI
- Form: Capsule injection, syrup or suppository.
- Brand name: Tigran®.
- Symptoms relieved: Nausea, vomiting.
- Precautions and possible side effects: Hypotension, blurred vision, drowsiness, dizziness, disorientation, uncontrollable muscle movements, and lip-smacking or chewing.
Generic name: Metoclopramide HCI
- Form: Syrup, tablet or injection.
- Brand name: Reglan®.
- Symptoms relieved: Nausea, vomiting.
- Precautions and possible side effects: Uncontrollable muscle movements, lip-smacking or chewing movements, sensitivity to sunlight, aching of lower legs, and diarrhea.
Generic name: Antihistamines cyproheptadine HCI
- Form: Syrup or tablet.
- Brand name: Periactin®.
- Symptoms relieved: Sleeplessness, length of migraine.
- Precautions and possible side effects: Weight gain, drowsiness.
Generic name: Diphenhydramine HCI
- Form: Tablet, liquid, liquid-gel.
- Brand name: Benadryl® (over-the-counter).
- Symptoms relieved: Nausea, vomiting
- Precautions and possible side effects: Sleepiness, dizziness, disturbed coordination, behavioral changes.
Fioricet is a Good Medication For Tension Headache
Fioricet is a medication that contains butalbital, acetaminophen, and caffeine, and is commonly used to treat tension headaches.
Butalbital/Acetaminophen/Caffeine is a prescription medication used to treat Tension Headaches.
- Butalbital/Acetaminophen/Caffeine is available under the following different brand names: Fioricet, Orbivan, Alagesic LQ, Dolgic Plus, Esgic Plus, Margesic, Zebutal
An overdose of Fioricet can be life-threatening, particularly due to the high risk of acetaminophen toxicity and butalbital’s sedative effects.
A migraine is a headache that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. It’s often accompanied by nausea, vomiting, and extreme sensitivity to light and sound. Migraine attacks can last for hours to days, and the pain can be so bad that it interferes with your daily activities.
For some people, a warning symptom known as an aura occurs before or with the headache. An aura can include visual disturbances, such as flashes of light or blind spots, or other disturbances, such as tingling on one side of the face or in an arm or leg and difficulty speaking.
Medications can help prevent some migraines and make them less painful. The right medicines, combined with self-help remedies and lifestyle changes, might help.
Symptoms
Migraines, which affect children and teenagers as well as adults, can progress through four stages: prodrome, aura, attack and post-drome. Not everyone who has migraines goes through all stages.
Prodrome
One or two days before a migraine, you might notice subtle changes that warn of an upcoming migraine, including:
- Constipation.
- Mood changes, from depression to euphoria.
- Food cravings.
- Neck stiffness.
- Increased urination.
- Fluid retention.
- Frequent yawning.
Migraine is a complex brain condition that affects nearly 1 billion people globally. Migraine is more than a strong headache. It can cause debilitating effects that can linger for days and disrupt daily life.
Fortunately, today there are many treatments to relieve migraine symptoms. Medications are one tool along with other support options to provide relief.
Fioricet is a combination medication that has been around for many years and is approved to treat symptoms of tension headaches. While it’s sometimes used for migraine, there are better choices available.
What is Fioricet?
Fioricet is the brand name multi-ingredient medication that’s used to treat some types of headaches. It’s also available in generic form.
Fioricet contains:
- butalbital 50mg
- acetaminophen 300mg
- caffeine 40mg
It’s FDA-approved to treat symptoms of a common type of headache known as tension headache but is also prescribed off-label for migraine.
How Fioricet Works for Headaches
- Tension Headaches: Fioricet helps alleviate the pain caused by muscle tension by relaxing the muscles and reducing pain signals.
- Migraines: Although not its primary indication, it is sometimes prescribed off-label for migraines, particularly if other treatments have not been effective.
Usage and Dosage
- The typical dosage is one to two tablets every four hours as needed, not exceeding six tablets per day.
- It’s important to follow your doctor’s prescription and not to self-medicate, as Fioricet contains acetaminophen, which can cause liver damage if taken in excessive amounts.
Why is Fioricet Used to Treat Migraine and Tension Headaches?
Fioricet is used to treat tension headaches and sometimes prescribed off-label for migraines because of its unique combination of active ingredients that address the symptoms and mechanisms of these headaches. Here’s a breakdown of why Fioricet is effective:
1. Combination of Ingredients
Fioricet contains three active components that work synergistically:
- Butalbital (Barbiturate):
- Relieves muscle tension, which is often a key factor in tension headaches.
- Has a sedative effect, helping to calm the central nervous system and reduce stress, which can trigger or exacerbate headaches.
- Acetaminophen (Pain Reliever):
- Reduces pain by inhibiting the production of prostaglandins, which are chemicals in the body responsible for causing pain and inflammation.
- Provides fast and effective relief for mild to moderate headache pain.
- Caffeine (Stimulant):
- Improves the absorption and effectiveness of acetaminophen.
- Causes vasoconstriction (narrowing of blood vessels), countering the vasodilation (widening of blood vessels) that is often associated with migraines.
2. Why It Works for Tension Headaches
Tension headaches are typically caused by muscle contraction and stress. Fioricet:
- Relaxes the muscles (butalbital).
- Provides pain relief (acetaminophen).
- Enhances blood flow and alleviates tightness (caffeine).
3.Why Fioricet Is Sometimes Used for Migraines
Migraines involve complex mechanisms, including changes in blood vessel size and pain sensitivity. Fioricet can help:
- Relieve migraine pain through acetaminophen and caffeine.
- Relax and calm the central nervous system with butalbital, which may help if stress or tension contributes to the migraine.
Fioricet may be an option if other migraine treatment options have not worked. Your doctor will just want to monitor you closely to avoid side effects.
It’s prescribed to help relieve immediate headache symptoms, but not to prevent migraine attacks.
How does Fioricet work to treat migraine?
Fioricet contains three different active ingredients which work together on tension headaches. The exact way Fioricet works to help relieve tension headache is not clear.
Butalbital is a barbiturate that helps with relaxation and anxiety, acetaminophen works as an analgesic for pain relief, and caffeine also helps with pain relief.
Limitations and Cautions
While Fioricet can be effective, it is not the first-line treatment for migraines or tension headaches. This is because:
- Risk of dependency: Butalbital is habit-forming, especially with prolonged use.
- Medication overuse headaches: Frequent use can lead to rebound headaches.
- Liver risk: Acetaminophen in high doses can cause liver damage, especially if combined with alcohol or other medications containing acetaminophen.
When to Use Fioricet ?
- It is typically prescribed when other medications, like over-the-counter pain relievers or migraine-specific drugs (e.g., triptans), are not effective.
- It’s more commonly used for tension headaches than migraines due to its mechanism of action.
How do you take Fioricet?
Fioricet is available as a capsule you take by mouth. The recommended dose is 1-2 capsules every 4 hours. Do not take more than 6 capsules in a 24-hour period.
Fioricet can cause an upset stomach, so taking it with food or milk may help. Ask your pharmacist for information on the best way to take Fioricet.
Warnings and Precautions
- Avoid alcohol: Alcohol increases the risk of liver damage due to acetaminophen and can enhance drowsiness.
- Medication overuse headaches (rebound headaches): Overuse of Fioricet may lead to this condition.
- Dependency: Butalbital can be habit-forming if used for an extended period.
- Health conditions: Inform your doctor if you have liver disease, kidney disease, or a history of substance abuse.
Adult and pediatric dosage
Tablet
- butalbital/acetaminophen/caffeine
- 50mg/325mg/40mg (Fioricet, Esgic)
- 50mg/500mg/40mg (Espic-Plus)
- 50mg/750mg/40mg (Dolgic Plus)
Capsule
- butalbital/acetaminophen/caffeine
- 50mg/300mg/40mg (Orbivan)
- 50mg/325mg/40mg (Esgic, Margesic)
- 50mg/500mg/40mg (Esgic-Plus, Zebutal)
Liquid, oral
- butalbital/acetaminophen/caffeine
- (50mg/325mg/40mg)15mL (Alagesic LQ)
Tension Headache
Adult dosage
- 50mg/300-325mg/40mg: 2 tablets or capsules orally every 4 hours; not to exceed 6 tablets or capsules/day
- 50mg/500mg/40mg: 1 tablet/capsule orally every 4 hours; not to exceed 6 tablets or capsules/day
- 50mg/750mg/40mg: 1 tablet/capsule orally every 4 hours; not to exceed 5 tablets or capsules/day
- 15-30 mL solution orally every 4 hours; not to exceed 180 mL solution/day
- Not to exceed 4 g/day of acetaminophen for any dosage form or regimen
Pediatric dosage
- Children younger than 12 years of age: Safety and efficacy not established
- Children 12 years of age or older:
- 50mg/300-325mg/40mg: 2 tablets or capsules orally every 4 hours; not to exceed 6 tablets or capsules/day
- 50mg/500mg/40mg: 1 tablet/capsule orally every 4 hours; not to exceed 6 tablets or capsules/day
- 50mg/750mg/40mg: 1 tablet/capsule orally every 4 hours; not to exceed 5 tablets or capsules/day
- 15-30 mL solution orally every 4 hours; not to exceed 90 mL solution/day
- Not to exceed 4 g/day of acetaminophen for any dosage form or regimen
What may interact with Fioricet?
- Alcohol or medications that contain alcohol
- Antidepressants, especially MAOIs like isocarboxazid, phenelzine, tranylcypromine, and selegiline
- Antihistamines
- Benzodiazepines
- Carbamazepine
- Isoniazid
- Medications for pain like pentazocine, buprenorphine, butorphanol, nalbuphine, tramadol, and propoxyphene
- Muscle relaxants
- Naltrexone
- Phenobarbital, phenytoin, and fosphenytoin
- Phenothiazines like perphenazine, thioridazine, chlorpromazine, mesoridazine, fluphenazine, prochlorperazine, promazine, and trifluoperazine
- Voriconazole
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What are the possible side effects of Taking Fioricet?
Share your medical history with your doctor and ask if Fioricet is safe for you to take. Fioricet can cause some serious side effects, including:
- confusion
- seizure
- depression
- drowsiness, dizziness
- feeling intoxicated
- stomach pain
- dry mouth
- heartburn
- fast heart rate
- muscle pain
- rash, itching
- vomiting
If you experience a severe or life-threatening reaction to Fioricet, call 911 right away.
Are there risks from taking Fioricet for migraine?
Fioricet has several risks and may not be suitable for everyone.
The active ingredient butalbital in Fioricet may be habit-forming. Using higher doses for a long time may lead to dependence on Fioricet. Suddenly stopping the medication after regular use may also cause withdrawal symptoms.
Drinking alcohol or taking other sedative medications with Fioricet may be harmful and cause dangerous side effects. Butalbital takes a long time to clear from your body.
Do not take Fioricet with other products that have the same active ingredients. Taking too much of these ingredients together can increase the risk of overdose, cause liver or kidney damage, and may be life-threatening.
Talk with your doctor about any medications and over-the-counter products you’re taking, including vitamins, herbs, and natural supplements.
Some examples include:
- acetaminophen (Tylenol, multi-symptom cough/cold products)
- caffeine (energy drinks, Excedrin migraine, caffeine pills)
- butalbital (barbiturates)
Taking Fioricet regularly can increase your risk for rebound headaches or medication overuse headaches. The American Migraine Prevalence and Prevention Study found use of butalbital for 5 days per month would increase the risk of acute migraine becoming chronic migraine.
Fioricet can raise blood pressure and heart rate, if you have a history of high blood pressure or heart related conditions, ask your doctor about the risks of Fioricet.
Symptoms of Fioricet Overdose
- Acetaminophen toxicity (liver damage):
- Nausea and vomiting
- Loss of appetite
- Pain in the upper right side of the abdomen
- Jaundice (yellowing of the skin or eyes)
- Fatigue and confusion
- Dark urine
- In severe cases: liver failure, coma, or death
- Butalbital toxicity (barbiturate overdose):
- Drowsiness or deep sedation
- Slurred speech
- Confusion or disorientation
- Difficulty breathing or respiratory depression (shallow, slow, or stopped breathing)
- Coma or unconsciousness
- Hypotension (low blood pressure)
- Shock
- Death (due to respiratory failure or circulatory collapse)
- Caffeine overdose:
- Restlessness or agitation
- Tremors
- Rapid heartbeat (tachycardia)
- Nausea and vomiting
- Seizures (in severe cases)
More Fioricet Butalbital APAP Caffeine Online Article
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- Warnings of Taking Fioricet Butalbital APAP Caffeine
- Buy Fioricet Butalbital APAP Caffeine Online
- What special precautions should I follow before I take Fioricet Butalbital APAP Caffeine ?
- Acetaminophen Over-dosage Warning
- What medications should I not take with butalbital-acetaminophen-caffeine?
- What Does Each Ingredient of Fioricet do?
- What Should I Avoid While Taking Fioricet?
- Fioricet Drug Interaction (5)
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- How Should I Use Esgic-Plus Butalbital APAP Caffeine
- Acetaminophen, Butalbital, and Caffeine
- Drug Interactions of Fioricet
- Does Fioricet Make you Sleepy?
- How has Fioricet Improved Patient Outcomes?
- Mixing Fioricet and Alcohol
- Taking Fioricet Safely: Know the Risks
- How Long Does Fioricet Stay in Your System?
- Is it Safe to use Fioricet During Pregnancy?
- BUTALBITAL ACETAMINOPHEN CAFFEINE treats tension headaches
Treatment for Fioricet Overdose
1. Immediate Action:
If an overdose is suspected, seek emergency medical help immediately by calling 911 or going to the nearest emergency room. Early treatment is critical to prevent life-threatening complications.
2. Activated Charcoal:
If the overdose is caught early (typically within 1–2 hours), activated charcoal may be administered to prevent further absorption of the drug from the gastrointestinal tract.
3. Acetaminophen Overdose Treatment:
Since acetaminophen toxicity can cause severe liver damage, treatment often includes:
- N-Acetylcysteine (NAC): This is the antidote for acetaminophen overdose. It helps to protect the liver and prevent damage if administered early. NAC is most effective when given within 8 hours of overdose but can be used up to 24 hours or more.
- Liver function monitoring: Regular monitoring of liver enzymes, clotting factors, and other markers will be necessary to evaluate the extent of liver damage.
4. Butalbital Overdose Treatment:
- Supportive care: Butalbital overdose can cause respiratory depression, so immediate interventions include monitoring and support for breathing, possibly involving oxygen or even mechanical ventilation.
- IV Fluids and Medications: IV fluids may be given to maintain blood pressure, and medications like vasopressors could be needed in cases of low blood pressure.
- Gastric lavage: Sometimes, stomach pumping (gastric lavage) is performed if the overdose was recent.
- Barbiturate antidotes: There are no specific antidotes for barbiturate poisoning, so treatment focuses on managing symptoms and supporting vital functions like breathing.
5. Caffeine Overdose Treatment:
- IV fluids: To help flush the caffeine from the system and manage dehydration or electrolyte imbalances.
- Beta-blockers: These may be used to control symptoms like rapid heartbeat or tremors.
Monitoring and Long-Term Care:
- Hospitalization: Severe overdoses often require intensive care in the hospital, especially if there are signs of respiratory depression or liver damage.
- Liver Transplant: In cases where acetaminophen toxicity leads to liver failure, a liver transplant may be necessary as a last resort.
- Psychiatric Evaluation: If the overdose was intentional, mental health evaluation and treatment for underlying conditions like depression or substance use disorders may be required.
- Addiction Treatment: Long-term treatment may involve addiction therapy if the overdose resulted from substance abuse.
Prevention Tips:
- Avoid exceeding prescribed doses: Fioricet should always be taken exactly as prescribed. Taking more than the prescribed amount, especially for longer periods, increases the risk of overdose.
- Avoid alcohol: Drinking alcohol while using Fioricet increases the risk of liver damage and worsens the sedative effects of butalbital.
- Monitor acetaminophen intake: Ensure that other medications being taken do not contain acetaminophen to prevent unintentional overdose.
- Use caution with other sedatives: Avoid using Fioricet with other sedative medications, such as benzodiazepines or opioids, as this can increase the risk of dangerous respiratory depression.
Butalbital Acetaminophen Caff Abuse, Treatment and Prevention
Butalbital, Acetaminophen, and Caffeine abuse can become a serious issue, especially because of the barbiturate component, butalbital, which is known to cause dependency. The abuse of this combination medication can lead to physical and psychological addiction, as well as serious health risks like liver damage from acetaminophen and other complications due to butalbital’s sedative effects.
Signs of Abuse:
- Overuse: Taking more than the prescribed dose or more frequently.
- Tolerance: Needing higher doses to achieve the same pain-relieving effect.
- Withdrawal: Experiencing symptoms like restlessness, anxiety, or tremors when not taking the drug.
- Doctor shopping: Seeking prescriptions from multiple providers.
- Behavioral changes: Mood swings, irritability, or social withdrawal.
Health Risks of Abuse:
- Physical dependence: Butalbital can cause physical dependency, meaning that withdrawal symptoms may appear when stopping the drug suddenly.
- Overdose: High doses can lead to dangerous respiratory depression, coma, or death (mainly due to the butalbital component).
- Acetaminophen toxicity: Chronic overuse of acetaminophen can cause severe liver damage or failure, especially if taken with alcohol.
- Cognitive impairment: Chronic use of butalbital can cause memory problems, confusion, and reduced mental clarity.
Treatment of Abuse:
- Medical Detoxification: Detox under medical supervision may be necessary to safely withdraw from butalbital. The process may involve gradually tapering off the medication to prevent severe withdrawal symptoms like seizures.
- Inpatient or Outpatient Rehabilitation: Both inpatient and outpatient treatment programs can be effective in addressing the psychological aspects of addiction. These programs offer therapy, support groups, and education about addiction.
- Cognitive Behavioral Therapy (CBT): This form of therapy is effective in helping patients identify triggers for abuse, develop healthier coping strategies, and prevent relapse.
- Medication-Assisted Treatment (MAT): In some cases, medications may be used to alleviate withdrawal symptoms or reduce cravings.
- Support Groups: Programs like Narcotics Anonymous (NA) or other 12-step programs can provide ongoing support and accountability.
Prevention of Abuse:
- Proper Use: Follow prescription guidelines strictly, taking the medication only as directed by a healthcare professional and never exceeding the prescribed dose or frequency.
- Short-Term Use: Butalbital-containing medications should be prescribed and used only for short-term treatment of headaches, as the risk of dependency increases with prolonged use.
- Regular Monitoring: Doctors should closely monitor patients who are prescribed this combination for any signs of dependency or overuse. Patients should also be honest about their use and any side effects.
- Alternatives: Patients with chronic headaches or migraines should discuss alternative treatments with their doctors. Non-addictive medications or non-drug therapies like physical therapy, stress management, or biofeedback might be more appropriate for long-term management.
- Avoid Alcohol: Alcohol should not be consumed while taking this medication, as it increases the risk of liver damage (due to acetaminophen) and enhances the sedative effects of butalbital.
Warning Signs to Address with Healthcare Providers:
- Using the medication for non-medical reasons, like anxiety or insomnia.
- Needing to refill the prescription more frequently than recommended.
- Seeking multiple prescriptions from different doctors.